A GROUP of researchers have found plants in Mahale National Park in Kigoma that could be used in breast cancer treatment.
The discovery is a culmination of a series of 40 years of research that might lead to the production of new drugs for hard-to-treat breast cancers. The medicine is extracted from the plants, christened centratherum anthelminticu, found in the national park, which is in Kigoma Region.
The findings were made by a group of researchers, including Michael Huffman, Chung Yeng Looi, Aditya Arya, Foo Kit Cheah, Bushra Muharram, Kok Hoong Leong, Khalit Mohamad, Won Fen Wong, Nitika Rai and Mohd Rais Mustafa.
"Vernodalin exhibits antimalarial and anti-bacterial activities and is a constituent of Vernonia amygdalina (Compositae), a plant ingested by wild chimpanzees, sometimes suffering from parasiterelated diseases in the Mahale Mountains National Park, Tanzania," the researchers note.
According to the researchers, only two studies have so far been done on anti-cancer effect of vernodalin, which demonstrated cytotoxic activity on melanoma and ovarian cancer cell lines and human arcinoma of the nasopharynx (KB).
These two studies mainly examined cell viability of vernodalin treated cancer cells by MTT based assays and less information was available on anticancer mechanism by vernodalin."
They added that to the best of their knowledge, this was the first report on cytotoxicity and mechanism of vernodalin on human breast cancer cells. After some extensive studies, the researchers said they discovered the existence of the anti-cancer substance in the grains of the plant, which is the main substance in cancer medicine.
The researchers have indicated that this is the first comprehensive study on cytotoxic and apoptotic mechanism of vernodalin isolated from the centratherum anthelminticum seeds in human breast cancer cells "to the best of their knowledge".
They added that overall, their data suggests a potential therapeutic value of vernodalin to be further developed as new anti-cancer drug.
Our data suggest a potential therapeutic value of vernodalin to be further developed as new anti-cancer drug. "Science is a slow mover ... we wouldn't have come this far if it weren't for the caring mother chimps and, of course, Mo who is quite obviously the 'star' of the movie we've just documented ... ," he said.
The findings by the researchers note that the plant has profound activity against MCF-7 human breast cancer cell line. "Through bioassay guided isolation, we identified vernodalin as the active compound responsible for the anti-cancer property in the plant.
Our collective data suggests that vernodalin inhibits cell growth," it notes. The findings in the report indicate potential therapeutic value of vernodalin while research in animal tumour models is necessary to confirm its anti-cancer activity in vivo.
"In this study, bioassay guided isolation of CACF extract led us to the identification of a potent compound vernodalin. Vernodalin is a sesquiterpene lactone isolated from various plant species, including the seeds of C. anthelmintica," notes the research.
The discovery is a culmination of a series of 40 years of research that might lead to the production of new drugs for hard-to-treat breast cancers. The medicine is extracted from the plants, christened centratherum anthelminticu, found in the national park, which is in Kigoma Region.
The findings were made by a group of researchers, including Michael Huffman, Chung Yeng Looi, Aditya Arya, Foo Kit Cheah, Bushra Muharram, Kok Hoong Leong, Khalit Mohamad, Won Fen Wong, Nitika Rai and Mohd Rais Mustafa.
"Vernodalin exhibits antimalarial and anti-bacterial activities and is a constituent of Vernonia amygdalina (Compositae), a plant ingested by wild chimpanzees, sometimes suffering from parasiterelated diseases in the Mahale Mountains National Park, Tanzania," the researchers note.
According to the researchers, only two studies have so far been done on anti-cancer effect of vernodalin, which demonstrated cytotoxic activity on melanoma and ovarian cancer cell lines and human arcinoma of the nasopharynx (KB).
These two studies mainly examined cell viability of vernodalin treated cancer cells by MTT based assays and less information was available on anticancer mechanism by vernodalin."
They added that to the best of their knowledge, this was the first report on cytotoxicity and mechanism of vernodalin on human breast cancer cells. After some extensive studies, the researchers said they discovered the existence of the anti-cancer substance in the grains of the plant, which is the main substance in cancer medicine.
The researchers have indicated that this is the first comprehensive study on cytotoxic and apoptotic mechanism of vernodalin isolated from the centratherum anthelminticum seeds in human breast cancer cells "to the best of their knowledge".
They added that overall, their data suggests a potential therapeutic value of vernodalin to be further developed as new anti-cancer drug.
Our data suggest a potential therapeutic value of vernodalin to be further developed as new anti-cancer drug. "Science is a slow mover ... we wouldn't have come this far if it weren't for the caring mother chimps and, of course, Mo who is quite obviously the 'star' of the movie we've just documented ... ," he said.
The findings by the researchers note that the plant has profound activity against MCF-7 human breast cancer cell line. "Through bioassay guided isolation, we identified vernodalin as the active compound responsible for the anti-cancer property in the plant.
Our collective data suggests that vernodalin inhibits cell growth," it notes. The findings in the report indicate potential therapeutic value of vernodalin while research in animal tumour models is necessary to confirm its anti-cancer activity in vivo.
"In this study, bioassay guided isolation of CACF extract led us to the identification of a potent compound vernodalin. Vernodalin is a sesquiterpene lactone isolated from various plant species, including the seeds of C. anthelmintica," notes the research.
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