Many
animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on
appetite and increase food intake. It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice.[
29] Moreover, CB1
receptors in the
hypothalamus may be involved in the motivational or reward aspects of eating.[
30]
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